STX17

Protein-coding gene in the species Homo sapiens
STX17
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4WY4,%%s4WY4

Identifiers
AliasesSTX17, syntaxin 17
External IDsOMIM: 604204; MGI: 1914977; HomoloGene: 9917; GeneCards: STX17; OMA:STX17 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for STX17
Genomic location for STX17
Band9q31.1Start99,906,654 bp[1]
End99,974,534 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for STX17
Genomic location for STX17
Band4|4 B1Start48,124,915 bp[2]
End48,186,507 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nipple

  • secondary oocyte

  • Achilles tendon

  • pylorus

  • skin of hip

  • corpus epididymis

  • caput epididymis

  • tail of epididymis

  • trabecular bone

  • cardia
Top expressed in
  • parotid gland

  • ciliary body

  • saccule

  • zygote

  • interventricular septum

  • spermatocyte

  • retinal pigment epithelium

  • lumbar subsegment of spinal cord

  • seminiferous tubule

  • iris
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • SNAP receptor activity
  • protein binding
  • protein phosphatase binding
  • protein kinase binding
  • SNARE binding
Cellular component
  • HOPS complex
  • cytoplasm
  • integral component of membrane
  • cytosol
  • mitochondria-associated endoplasmic reticulum membrane
  • rough endoplasmic reticulum
  • endoplasmic reticulum membrane
  • membrane
  • lysosomal membrane
  • autophagosome membrane
  • SNARE complex
  • smooth endoplasmic reticulum membrane
  • endoplasmic reticulum
  • mitochondrion
  • ER to Golgi transport vesicle membrane
  • COPII-coated ER to Golgi transport vesicle
  • endoplasmic reticulum-Golgi intermediate compartment membrane
  • cytoplasmic vesicle
  • endoplasmic reticulum-Golgi intermediate compartment
  • autophagosome
  • plasma membrane
  • endomembrane system
Biological process
  • endoplasmic reticulum-Golgi intermediate compartment organization
  • Golgi organization
  • protein localization to phagophore assembly site
  • autophagy
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • vesicle docking
  • autophagosome maturation
  • intracellular protein transport
  • vesicle fusion
  • vesicle-mediated transport
  • autophagosome membrane docking
  • exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55014

67727

Ensembl

ENSG00000136874

ENSMUSG00000061455

UniProt

P56962

Q9D0I4

RefSeq (mRNA)

NM_017919

NM_026343

RefSeq (protein)

NP_060389

NP_080619

Location (UCSC)Chr 9: 99.91 – 99.97 MbChr 4: 48.12 – 48.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syntaxin 17 is a protein that in humans is encoded by the STX17 gene.[5] In horses a duplication in intron 6 causes progressive graying.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136874 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061455 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Syntaxin 17".
  6. ^ "UC Davis Gray".

Further reading

  • Itakura E, Kishi-Itakura C, Mizushima N (2012). "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes". Cell. 151 (6): 1256–69. doi:10.1016/j.cell.2012.11.001. PMID 23217709.
  • Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM (2010). "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity". Nature. 466 (7302): 113–7. Bibcode:2010Natur.466..113P. doi:10.1038/nature09114. PMC 2921172. PMID 20596022.
  • Muppirala M, Gupta V, Swarup G (2011). "Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi". Biol. Cell. 103 (7): 333–50. doi:10.1042/BC20110006. PMID 21545355. S2CID 41507139.
  • Zhao ZZ, Duffy DL, Thomas SA, Martin NG, Hayward NK, Montgomery GW (2009). "Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma". Melanoma Res. 19 (2): 80–6. doi:10.1097/CMR.0b013e328322fc45. PMC 3665505. PMID 19209086.
  • Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
  • Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/s0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
  • Steegmaier M, Oorschot V, Klumperman J, Scheller RH (2000). "Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics". Mol. Biol. Cell. 11 (8): 2719–31. doi:10.1091/mbc.11.8.2719. PMC 14951. PMID 10930465.

External links

  • Overview of all the structural information available in the PDB for UniProt: P56962 (Human Syntaxin-17 (STX17)) at the PDBe-KB.


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